Spinal cord injury patients receiving BMMSC show improvements compared to control group

This 2013 study features a treatment group (who received bone marrow mesenchymal stem cells)  and a control group (who did not receive cells). 20 patients were in the treatment group and 20 in the control group, for a total of 40 patients with spinal cord injuries. The MSCs were harvested from the bone marrow of the participants. Only mild adverse events (fever and headache) were reported in the treatment group. Patients who did not receive cells showed no improvement after 6 months. Half (10/20) of those who received bone marrow MSC showed improvements in motor or sensory function, or in ASIA grades (9/20). The differences in scores between those who did not receive cells and those who did receive BMMSC were statistically significant.


Brain Res. 2013 Oct 2;1533:73-9. doi:10.1016/j.brainres.2013.08.016. Epub 2013 Aug 12.

Transplantation of autologous bone marrow mesenchymal stem cells in the treatment of complete and chronic cervical spinal cord injury.

Dai G, Liu X, Zhang Z, Yang Z, Dai Y, Xu R.

Abstract

Neuronal injuries have been a challenging problem for treatment, especially in the case of complete and chronic cervical spinal cord injury (SCI). Recently, particular attention is paid to the potential of stem cell in treating SCI, but there are only few clinical studies and insufficient data. This study explored the efficacy of autologous bone marrow mesenchymal stem cells (BMMSCs) transplantation in the treatment of SCI. Forty patients with complete and chronic cervical SCI were selected and randomly assigned to one of the two experimental groups, treatment group and control group. The treatment group received BMMSCs transplantation to the area surrounding injury, while the control group was not treated with any cell transplantation. Both the transplant recipients and the control group were followed up to 6 months, postoperatively. Preoperative and postoperative neurological functions were evaluated with AIS grading, ASIA score, residual urine volume and neurophysiological examination. Results showed that in the treatment group 10 patients had a significant clinical improvement in terms of motor, light touch, pin prick sensory and residual urine volume, while nine patients showed changes in AIS grade. Neurophysiological examination was consistent with clinical observations. No sign of tumor was evident until 6 months postoperatively. In the control group, no improvement was observed in any of the neurological functions specified above. BMMSCs transplantation improves neurological function in patients with complete and chronic cervical SCI, providing valuable information on applications of BMMSCs for the treatment of SCI.


PMID: 23948102